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Engineering and Manufacturing of Microfluidic Systems

MICROFLUIDIC SYSTEMS

Wingflow specializes in the development and production of special equipment for microfluidics. The delivery program includes standard and customized systems for laboratories as well as equipment for pilot and production scale. Components produced by Wingflow and partner companies are engineered and upscaled into new and existing turnkey systems. The design and assembly of the pilot plants are based on findings from laboratory-scale experiments supervised by Wingflow specialists. In each specific case customer-specific solutions are developed and implemented.

  • Chemical Laboratories
  • Pharmaceutical Laboratories
  • Clinical & Medical Laboratories
  • Chemical Plants
  • Pharmaceutical Productions
  • Clinical and Medical Institutions
Laboratory Systems
100%
Pilot and Production Systems
100%

Series: Qmix, Wmix

Laboratory Systems
Customer specific designs are avaliable on request.

  • Model: Qmix Pro Lab
  • Media: liquids
  • Applications: synthesis, encapsulation, droplet generation

Series: CombiFlow, ProFlow

Pilot and Production Systems
Customer specific designs are avaliable on request.

  • Model: CombiFlow V02
  • Media: gases and liquids
  • Applications: synthesis, encapsulation, droplet generation

Series: Qmix OoC, Wmix IVFoC

Laboratory Systems for Organ-on-a-Chip and In Vitro Fertilization-on-a-Chip

  • Model: Qmix OoC
  • Media: gases and liquids
  • Application: Organ-on-a-Chip
  • Developed by: Wingflow AG

Series: CTCelect

Laboratory Systems for Enrichment and Isolation of Circulating Tumor Cells

  • Model: CTCelect
  • Media: liquids
  • Application: Isolation of CTC
  • Developed by: Fraunhofer IMM
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Realized Projects

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Units of Lab Equipment

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Units of Pilot Equipment

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Installed Industry Plants

MICROFLUIDIC COMPONENTS

MICROFLUIDIC CHIPS

Our scope of delivery includes standard chips for various applications as well as customer specific chips that can be customized and manufactured on request.

Glass Chips

Wingflow offers various microfluidic glass reactors for continuous flow mode. This material is ideally suited for a wide range of microfluidic applications, since it is also resistant to difficult environmental influences, and at the same time displays a high degree of biocompatibility. In addition to chips for chemical and pharmaceutical applications, we offer customized glass chips for biomedical purposes (organ-on-a-chip, lab-on-a-chip, IVF-on-a-chip).

Droplet Chips T SERIES

The T series contains sheath flow droplet generation microfluidic chips used e.g. for encapsulation of Active Pharmaceutical Ingredient (API) as well as spherical particle generation. Chips are connected with a chip holder (PEEK, Al are avaliable) or by standard fittings. Customer specific designs are avaliable on request.

  • T-25 Droplet Chip
  • Size: 25 * 75 * 1,0 mm
  • Volume of mixing zone: 0.47 µl
  • Volume of reaction zone: 3.30 µl
  • Inlets / Outlets: 3-1
  • T-28 Droplet Chip
  • Size: 25 * 75 * 1,0 mm
  • Volume of mixing zone: 0.60 µl
  • Volume of reaction zone: 1.90 µl
  • Inlets / Outlets: 3-1
  • T-26 Droplet Chip
  • Size: 25 * 75 * 1,0 mm
  • Volume of mixing zone: 0.47 µl
  • Volume of reaction zone: 3.30 µl
  • Inlets / Outlets: 3-1
  • T-29 Herringsbone Chip
  • Size: 25 * 75 * 1,0 mm
  • Volume of mixing zone: 0.47 µl
  • Volume of reaction zone: 3.30 µl
  • Inlets / Outlets: 2-1
  • T-27 Droplet Chip
  • Size: 25 * 75 * 1,0 mm
  • Volume of mixing zone: 0.60 µl
  • Volume of reaction zone: 3.30 µl
  • Inlets / Outlets: 3-1
  • Chip Holder 25x75
  • Chip size: 25 * 75 * 1,0 mm
  • Connectors: UNF 1/4”-28
  • Material: PEEK or Al
  • Inlets / Outlets: 3-1

MR-LAB SERIES

The MR-Lab series consists of Micromixer Type S and Type X, Microreactors Type V and Type VS, Aluminium connecting bar with additional frame for up to 5 reactors and stage clamp. The MR-Lab series is made of borosilicate glass, has no dead volume, is simple to operate and has space-saving in use. They are pressure stable up to 15 bar. Customer specific designs are avaliable on request.

  • Micromixer MR Lab MS
  • Size: 115 * 60 * 6 mm
  • Volume: 0.2 ml
  • Channel size: 1 mm
  • Mixing Zone
  • Micromixer MR Lab MX
  • Size: 115 * 60 * 6 mm
  • Volume: 0.2 ml
  • Channel size: 1 mm
  • Intensive Mixing Zone
  • Microreactor MR Lab V
  • Size: 115 * 60 * 6 mm
  • Volume 1.7 ml
  • Channelsize: 1 mm
  • Reaction Zone
  • Microreactor MR Lab VS
  • Size: 115 * 60 * 6 mm
  • Volume: 1.1 ml
  • Channel size: 1 mm
  • Reaction Zone

HTM SERIES

The HTM series microreactors were developed as an experimental platform, the use of which precedes the transmission into larger components, the XXL reactors. HTM components are available with and without heat exchangers (HE). The material is borosilicate glass. Microreactors of the HTM series are stable under pressure up to 20 bar. Customer specific designs are avaliable on request.

  • Micromixer Type X
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.06 ml
  • Permitted particle size 30 µm
  • Micromixer Type S
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.10 ml
  • Permitted particle size 150 µm
  • Micromixer Type ST
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.06 ml
  • Permitted particle size 50 µm
  • Micromixer Type ST 2-1
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.12 ml
  • Permitted particle size 50 µm
  • Micromixer Type ST 3-1
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.10 ml
  • Permitted particle size 50 µm
  • Microreactor Type KOE
  • Size: 90 * 54 * 2 mm without HE
  • Size: 90 * 54 * 9 mm with HE
  • Volume: 0.50 ml
  • Permitted particle size 250 µm
  • Microreactor XXL-KOE-01
  • Size: 150 * 50 * 9 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 1-1

MR-PILOT SERIES

The MR-Pilot series permits the implementation of the results investigated in the lab into bigger scales. The MR-Pilot reactors are made from borosilicate glass. The reactors are connected about a connection rail. They are pressure resistant up to 10 bar, higher stability is individually possible on inquiry. Customer specific designs are avaliable on request.

  • MR-Pilot-1
  • Size: 250 x 100 x 6,4 ±0,5 mm
  • Volume: 1 ml + 2 ml
  • Material: Borofloat33
  • Mixing and Reaction Zone
  • MR-Pilot-2
  • Size: 250 x 100 x 6,4 ±0,5 mm
  • Volume: 4 ml
  • Material: Borofloat33
  • Reaction Zone
  • MR-Pilot-3
  • Size: 250 x 100 x 6,4 ±0,5 mm
  • Volume: 8 ml
  • Material: Borofloat33
  • Reaction Zone
  • MR-Pilot-4
  • Size: 250 x 100 x 6,4 ±0,5 mm
  • Volume: 16 ml
  • Material: Borofloat33
  • Reaction Zone

XXL SERIES

The XXL series permits the large-scale implementation of the results of laboratory research. The reactors with integrated heat exchangers are connected via glass internal screws or hollow screws with clamping ring connection for the thermostat. The borosilicate glass microreactors are stable under pressure up to 20 bar. Customer specific designs are avaliable on request.

  • Microreactor XXL-ST-01
  • Size: 150 * 150 * 14 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 3-1
  • Microreactor XXL-ST-02
  • Size: 150 * 150 * 14 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 1-1
  • Microreactor XXL-ST-03
  • Size: 150 * 150 * 14 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 2-1
  • Microreactor XXL-ST-04
  • Size: 150 * 150 * 14 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 2-3
  • Microreactor XXL-ST-05
  • Size: 150 * 150 * 14 mm
  • Volume: 8.0 ml
  • Capillary Length: 3000 mm
  • Inlets / Outlets: 3-1
  • Microreactor XXL-S-01
  • Size: 190 * 120 * 6,6 mm
  • Volume:15.0 ml
  • Capillary Length: 2000 mm
  • Inlets / Outlets: 3-1
  • Microreactor XXL-S-02
  • Size: 180 * 130 * 6.4 mm
  • Volume 15.0 ml
  • Capillary Length: 2000 mm
  • Inlets / Outlets: 2-1

Stainless Steel Chips

Wingflow has microfluidic chips made of stainless steel in its delivery program. This material is particularly useful for reactions at high temperatures and high pressures.

WF-LAB SS-Series

The WF-Lab SS series consists of various chips with different capillary structures. The types with mixing and reaction zones are available. The maximum working pressures are from 5 to 200 bar, depending on the version. Customer specific designs are avaliable on request.

  • Microreactor WF-Lab SS-1
  • Size: 35 * 35 * 3,3 mm
  • Volume: 3,0 ml
  • Channel size: 0,8 mm
  • Mixing and Reaction Zone

WF-PILOT SS-Series

The WF-Pilot SS series permits the implementation of the results investigated in the lab into bigger scales. Pilot series stainless steel chips are fitted with thermostats. Depending on the requirements, working pressures are up to 20 bar. Customer specific designs are avaliable on request.

  • Microreactor WF-Pilot SS-1
  • Size: 240 * 120 * 20 ± 0,5 mm
  • Volume: 20 ml
  • Channel size: 1,2 * 2,0 mm
  • Mixing and Reaction Zone

MICROFLUIDIC DOSING SYSTEMS

Precise dosing is the key to operation of microfluidic systems. We offer dosing systems for liquids and gases to suit the customer needs.

Syringe Pumps neMESYS

Continuous flow syringe pumps cetoni neMESYS series for biological and medicinal applications.

  • Syringe Pumps neMESYS M
  • Max. operating pressure: 200 bar

Syringe Pumps Wmix

Continuous flow syringe pumps Wingflow Wmix series for chemical and pharmaceutical applications.

  • Syringe Pumps Wmix
  • Max. operating pressure: 50 bar

Gas Compressor Stations

The compact Wingflow gas stations, which are equipped with Haskel compressors and adjustable valves, are used for the safe and continuous dosing of gases.

  • Gas Station GB-1178 AG-75
  • Max. operating pressure: 600 bar
  • Pressure regulator: 3.5 - 414 bar
  • High pressure reservoir: 3 l
  • Media: H2, O2, N2, Ar, CO2

Mass Flow Controllers

Bronkhorst MINI CORI-FLOW™ series coriolis mass flow meters & controllers are designed for accurate measurement and dosing of gases and liquids.

  • MINI CORI-FLOW™ series
  • Lowest range: 0…5 g/h
  • Highest range: 0…300 kg/h
  • Pressure rating: up to 200 bar
  • Measurement method: Coriolis

Main Microfluidic Applications

Main Applications of Our Customers in the Field of Microfluidics

Microfluidic Synthesis

Continuous flow microfluidic has the potential to greatly improve efficiency in the synthesis of most active pharmaceutical ingredients.

Microfluidic Encapsulation

Microfluidic encapsulation has long been recognized as a way of improving the uptake and release of active pharmaceutical ingredients.

CTC-on-Chip

Microfluidic technology is increasingly used for isolation, identification and characterization of Circulating Tumor Cells (CTC).

Organ-on-Chip

Organ-on-chip is a micro-scale system used for mimicking the human body environment by human tissue models for disease modeling and drug testing.

Lab-on-Cip

Lab-on-chip is a class of device that integrates and automates multiple laboratory techniques into a system that fits on a small microfluidic chip.

IVF-on-Chip

Microfluidic offers unique opportuni-ties to automate IVF procedures, redu-ce stress imposed upon gametes and embryos, and minimize human factor.

Microfluidic System Order Form

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